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Manipularea tisulară Standardizarea prelucrarii tesutului pentru pacientii cu CmCR rămâne inca o provocare. Timpul scurs din momentul prelevarii probelor de țesut pana la cancer rectal nccn ar trebui să fie redus la minimum, la numai câteva minute dacă este posibil, pentru a evita orice degradare a proteinelor și a acizilor nucleici care ar putea să apară în timpul ischemiei reci. Timpul de fixare ar trebui să fie între 6 și 48 de ore.

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Factorii de risc semnificativi sunt prezena adenopatiilor metastatice i invazia profund n peretele intestinal. Recidivele locale n absena bolii metastatice sunt mult mai frecvente n cancerul rectal spre deosebire de cancerele de colon.

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