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Rationale: Cervical cancer figo stage new theory named ontogenetic compartment theory has been proposed by Michael Hȍckeland and is based on the fact that tumor growth is restricted to certain compartments which have their origin in the same primordium during the ontogenesis. A completere section of this compartment has the advantage of avoiding removal of adjacent tissues with other embryonic origin, whereas an incomplete removal of the compartment is associated with a high risk of tumor recurrence and poor local control.

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The biologic behavior of cervical cancer figo stage cervical carcinoma after neoadjuvant therapy NAT according to immunohistochemical expression cervical cancer figo stage E-cadherin and CD44v6 Mihaela Madalina Gavrilescu, Raluca Balan, Viorel Scripcariu, Dan Ferariu, Ludmila Lozneanu, Diana Popovici, Cornelia Amalinei Abstract The efficiency of neoadjuvant therapy in cervical carcinoma has been well demonstrated, although the cellular mechanisms of different response to this treatment have not been thoroughly investigated. The aim of our study was to assess the correlations between the alterations in E-cadherin and CD44v6 immunoexpression in cervical carcinoma, as a tool of evaluation the response to neoadjuvant therapy and its prognostic significance. The intensity of CD44v6 immunoexpression was higher in more aggressive tumors and E-cadherin immunoexpression was approximately constant among the cases with neoadjuvant therapy.

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Corresponding author: Dr. Maria Alexandra Barbu, e-mail: m.

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