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The biologic behavior of squamous cervical carcinoma after neoadjuvant therapy NAT according to immunohistochemical expression of E-cadherin and CD44v6 Mihaela Madalina Gavrilescu, Raluca Balan, Viorel Scripcariu, Dan Ferariu, Ludmila Lozneanu, Diana Popovici, Cornelia Amalinei Abstract The efficiency of neoadjuvant therapy in cervical carcinoma has been well demonstrated, although the cellular mechanisms of different response to this treatment have not been thoroughly investigated. The aim of our study was to assess the correlations between the alterations in E-cadherin and CD44v6 immunoexpression in cervical carcinoma, as a tool of evaluation the response to neoadjuvant therapy and its prognostic significance. The cervical cancer metastatic sites of CD44v6 immunoexpression was higher in more aggressive tumors and E-cadherin immunoexpression was approximately constant among the cases with neoadjuvant therapy.

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Facing such a scenario, the only solution is following a sequence of investigations and therapy steps towards a correct and complete diagnosis if possible. We review the current literature data and present a personal case.

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Наверное, ты прав, - задумчиво проговорила Николь. - Но меня угнетает, что как вид мы ведем себя столь варварским образом, даже когда можно не сомневаться, что за нами следят.

- Помолчав, она продолжила: - Итак, по-твоему, долгое взаимодействие человечества с раманами, начавшееся с прилета первого корабля более сотни лет назад, наконец завершается.

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