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Depending on the stage of tumor invasion and its aggressiveness, is individualized, surgical, oncological, or both treatment. The most important factor for establishing these protocols is colorectal cancer blood markers impact of the tumor on intra- and perilesional colorectal vasculature and implicitly on the process of vascular neoformation in the paraneoplastic syndrome.

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Based on recent epidemiological data showing an increase in CRC incidence around the age of 50 years old, the American Cancer Society made a qualified re­com­men­dation to lower the age for starting the screening from 50 to 45 years old for all average-risk individuals. Ac­cor­ding to the American Cancer Society, a qualified re­com­mendation indicates clear evidence colorectal cancer blood markers benefits, but less certainty about the risk-be­ne­fits balance.

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