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TR Microsatellite instability MSI Instabilitatea microsatelitară MSI este o afecțiune care apare pe ADN-ul celulelor specifice cum ar fi celulele canceroase unde numărul de microsateliți endometrial cancer microsatellite instability scurte ale secvențelor ADN din aceste celule este diferit de repetările care au existat în ADN atunci când a fost moștenit. Această instabilitate este cauzată de funcționarea defectuoasă a mecanismului de reparare mecanismul de reparare a erorilor de replicare ADN, MMR a erorilor în timpul replicării ADN-ului. Microsateliții, sau tandemuri scurte repetitive, sunt secvențe repetitive de ADN cu funcție necunoscută în genom, care apar stabile pe durata existenței unui individ.

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Hiperplazia endometriala poate aparea la orice varsta si risca sa se care se poate corela cu severitatea afecțiunii hiperplazie sau cancer. Totuși, evoluția sa depinde de factorii de risc personali și mai ales de tipul.

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Results: There were selected, for these immunohistochemistry reactions, 22 cases of simple hyperplasia without atypia, 26 cases of complex hyperplasia without atypia, 23 cases of endometrial adenocarcinoma of endometrioid type, well differentiated, 22 cases of endometrial adenocarcinoma of endometrioid type, moderately differentiated, and 19 cases of non-endometrioid adenocarcinomas represented by nine clear cells and 10 serous endometrial adenocarcinomas. Conclusions: Endometrial hyperplasia, especially complex endometrial hyperplasia with atypia, increase the risk for endometrial adenocarcinoma, and their early detection becomes mandatory under cancer prevention. Well-differentiated endometrioid endometrial adenocarcinomas GI in the studied group also showed a higher content of ER and PR compared to the endometrial moderately-differentiated endometrioid endometrial adenocarcinomas GII. In non-endometrioid adenocarcinomas, represented endometrial cancer microsatellite instability clear-cell endometrial adenocarcinomas, the ER content was reduced and the PR expression was negative.