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The patient initially received palliative chemotherapy with Paclitaxel, discontinued due to allergic reactions, and targeted therapy with Herceptin. BM were treated with antalgic radiotherapy and bisphosphonates. After the occurrence of secondary brain lesions, the patient underwent palliative whole-brain radiotherapy WBRT and systemic treatment with Capecitabine and Lapatinib from February In FebruaryLapatinib was replaced with Trastuzumab emtansine, after the approval of this drug in Romania.

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Discussion: A small number of patients with lung metastatic cancer in brain has a limited number of extra-thoracic metastases oligometastases. Some of these patients may benefit from resection of both primary and metastatic sites, in addition to systemic treatment, with the goal of increasing survival and achieving curability. Retrospective studies show that patients with oligometastatic lung cancer can achieve long-term survival if the surgical treatment achieves complete resection of the primary and all evident metastatic sites.

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