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Nicolau Institute of Virology, Bucharest, Romania. Introduction: In human cancer cells DNMTs are responsible for both de novo and maintenance methylation of tumor suppressor genes. Design: 49 patients aged 10–82 years hospitalized for thyroidectomy were included between January and July The inclusion criterion was patients with thyroid nodules with indication for surgery and the exclusion criteria were: hyperthyroidism, medullary thyroid carcinoma, thyroid metastasis, other thyroid tumors, and anaplastic thyroid carcinoma.

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