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Malignancies in this region present a variety of pathologies, each with distinct prop- erties. These tumors have different levels of involvement with the surrounding critical structures, including the brain and orbit. Sinonasal malignancies have diverse pathologies, with the most common being epithelial tumors [4].

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Studiul are avantajul ca aduce un element in plus si anume terapia cu NKTR care va fi testata in combinatie cu Nivolumab, ultimul- un tratament standard deja aprobat la noi in tara. NKTR este un agonist- adica stimuleaza activitatea sistemului imunitar prin marirea numarului de limfocite T si NK natural killer care au un rol activ in eliminarea tumorilor din organism.

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Frequently, a mandible resection is required in order to obtain safe oncologic margins. The prognosis is good, with a higher overall survival rate than in other oral malignancies. Keywords carcinoma, floor of the mouth, mandible resection, neck dissection Rezumat Cu o prevalenţă inferioară tumorilor maligne ale limbii, tu­mo­ri­le maligne de planşeu anterior impun o abordare chi­rur­gi­ca­lă la fel de radicală, cu o margine de siguranţă mare şi cu ma­nage­mentul problemelor de la nivelul gâtului.

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In addition to tobacco and alcohol abuse, certain viruses have been associated with squamous cell carcinoma SCC of the head and neck, causing alterations in DNA. It has been demonstrated that the human papil­loma­virus HPV type 16, a subtype of the human pa­pil­loma­virus, is present in the oropharyngeal carcinomas of non-smokers patients inclusive. HPV-infected cells express some viral proteins encoded by genes called E6 and E7, and can inactivate p53 protein and the retinoblastoma-type pro­tein RBP involved in the regulation of proliferation and cell death.

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